Canine Immune Complete International Formula is Here!
Due to the popularity of the Canine Immune Complete (CIC) formula for the United States market many located in other countries are demanding a special formulation of CIC that meets international standards, such as absence of animal organ or tissue ingredients.
CIC international is made according to GMP standards (human food supplement standards) and is available in Capsule form for your pets. These capsules can be opened, and the CIC formula may be delivered to your pet in powder form placed in their food or, depending on the size of the pet, the capsules may be delivered directly as an oral supplement.
Key CIC International Ingredients:
TRANSFER FACTOR (TF)
Transfer factor molecules provide your immune system with the information it needs to:
- Recognize pathogens like virus, bacteria, fungal, parasites, etc. Respond by killing these pathogens
- Remember them when they come back
Transfer factors are molecules that “educate” cells by binding to antigens without being consumed. Unlike antibodies, transfer factors give the immune system the ability to identify harmful bacteria or viruses so that it continues to adapt to new threats while providing balanced self-regulation to help prevent adverse health conditions.
Transfer Factor is a scientifically proven means of immune communication at the cellular level. Produced by the immune system, it is naturally designed to transfer highly concentrated, easily usable immune intelligence from one immune system to another, as from a human mother to her baby through her colostrum or “first milk.”
Transfer Factor Molecules are Polypeptides (PRPs), molecules filtered and concentrated from cow (bovine) colostrum as contained in CIC International. They are known for their ability to pass effortlessly through the digestive tract and help regulate immune response.
TF enables all animal mothers to pass their lifetime “database” on encounters with infective agents to their newborn offspring.
A transfer factor is a chemical that is taken from a human or animal that has already developed protection (immunity) against a certain diseases.
Transfer factors are essentially small immune messenger molecules that are produced by all higher organisms. They are an ancient part of the immune system and represent “an archaic dialect in the language of cells.”
TF is trans-species meaning that it works uniquely in multiple species. Transfer factor molecules have also proven to be essentially identical among different species, and therefore capable of communicating immune system knowledge from species to species. For example, TF from cow colostrum has the same positive action of transferring immunity information for a calf as it does for a dog or a human.
While antibiotics and other drugs tend to work instead of the immune system, transfer factor naturally supports the immune system.
- “The influence of age on Transfer factor treatment of cellular immunodeficiency, Chronic Fatigue Syndrome and/or chronic viral infections.”
- “Transfer factors: Identification of conserved sequences in transfer factor molecules.”
- “Use of Transfer factor for the treatment of recurrent non-bacterial female cystitis (NRBC): A preliminary report.” See also “Lessons from a pilot study of Transfer factor in Chronic Fatigue Syndrome.”
- “The relationship between Fibromyalgia and interstitial cystitis.”
- “Systemic aspects of interstitial cystitis, immunology and linkage with autoimmune disorders.”
- “Physiopathologic relationship between interstitial cystitis and rheumatic, autoimmune, and chronic inflammatory diseases.”
AFA or Aphanizomenon flos-aquae is a fresh water algae with tiny grass-like leaves.
At VPH we have micronized this material as used in CIC International to optimize its potency and for maximum assimilation and bioavailability.
Dr. Gitte S. Jensen, discovered that eating Aphanizomenon flos-aquae triggers the movement of up to 40% of the circulating NK cells (natural Killer White Blood Cells) from the blood to the tissues where their main function is to perform immune surveillance and eliminate bacterial or virally-infected cells.
- Jensen, Gitte S.; Ginsberg, Donald I.; Drapeau, Christian (2001). “Blue-Green Algae as an Immuno-Enhancer and Biomodulator” (PDF). Journal of the American Nutraceutical Association. 3 (4): 24–30. Archived from the original (PDF) on 26 April 2012. Retrieved 18 May 2012.
- Karina Preußela, Fastnera Jutta; Federal Environmental Agency, FG II 3.3, Corrensplatz 1, 14195 Berlin, Germany; Department of Limnology of Stratified Lakes, Institute of Freshwater Ecology and Inland Fisheries, Alte Fischerhütte 2, 16775 Stechlin, Germany; 15 October 2005.
CIC International™ contains a proprietary blend of mushrooms known for their immune system support including:
- Lion’s Mane
These mushrooms also contain glucans which support the positive functioning of TF and contain naturally occurring glutamine peptides that contribute to balancing or lowering cortisol levels contributing to the reduction of stress-related issues.
CIC International™ contains a proprietary blend of enzymes for good digestion of the CIC formula and also for support and balance of healthy, daily digestive functions.
The enzymes include:
- Acid Protease
- Superoxide Dismutase
CIC International™ contains micronized Shilajit. Shilajit is a traditional herbal remedy for general strengthening, endurance, rejuvenation, good nerve function, immune strengthening and good digestive health.
Known historically as the “Destroyer of Weakness”, Shilajit has naturally occurring Fulvic Acid and Humic Acid to help support general immune health and detoxification.
In traditional medicine Shilajit is considered a panacea herbal remedy since it has so many positive benefits for supporting good health, strengthening and general vitality.
- Ghosal S, Reddy JP, Lal VK Shilajit I: chemical constituents. J Pharm Sci. (1976)
- Acharya SB, et al Pharmacological actions of Shilajit. Indian J Exp Biol. (1988)
- Agarwal SP, et al Shilajit: a review. Phytother Res. (2007)
- Meena H, et al Shilajit: A panacea for high-altitude problems. Int J Ayurveda Res. (2010)The need for formulation of shilajit by its isolated active constituents
- Bucci LR Selected herbals and human exercise performance. Am J Clin Nutr. (2000)
- Biswas TK, et al Clinical evaluation of spermatogenic activity of processed Shilajit in oligospermia. Andrologia. (2010)
Ashwagandha is a traditional herb known for its adaptogenic qualities. As a powerful adaptogen, Ashwagandha increases an individual’s ability to adapt to environmental stresses and factors and helps to reduce damage to the body from these factors.
Ashwagandha is known to help reduce Cortisol by reducing oxidative stress associated with physical and mental stress leading to high Cortisol levels, thereby, assisting immune system functioning.
- Archana R, Namasivayam A. Antistressor effect of Withania somnifera.J Ethnopharmacol. 1999;64:91–93. [PubMed]
- Atta-ur-Rahman, Samina-Abbas, Dur-e-Shahwar, Jamal SA, Choudhary MI, Abbas S. New withanolides from Withania spp. Journal of Natural Products. 1991;56:1000–1006.
- Begum VH, Sadique J. Effect Of Withania-Somnifera On Glycosaminoglycan Synthesis in Carrageenin-Induced Air Pouch Granuloma. Biochemical Medicine and Metabolic Biology. 1987;38(3):272–277.[PubMed]
- Bhandari CR. Ashwagandha (Withania somnifera) “Vanaushadhi Chandroday” (An Encyclopedia of Indian Herbs) Vol. 1. Varanasi, India: CS Series of Varanasi Vidyavilas Press; 1970. pp. 96–97.
- Bhattacharya SK, Goel RK, Kaur R, Ghosal S. Anti – stress activity of Sitoindosides VII and VIII. New Acylsterylglucosides from Withania somnifera. Phytother Res. 1987;1:32–37.
- Bhattacharya SK, Kumar A, Ghosal S. Effects of glycowithanolides from Withania somniferaon animal model of Alzheimer’s disease and perturbed central cholinergic markers of cognition in rats. Phytother Res. 1995;9:110–113. Budhiraja RD, Sudhir S. Review of biological activity of withanolides. JSIR. 1987;46:488–491.
- Changhadi Govardhan Sharma, author. Ashwagandharishta – Rastantra Sar Evam Sidhyaprayog Sangrah – Krishna-Gopal Ayurveda Bhawan (Dharmarth Trust) Nagpur: 1938. pp. 743–744.
- Dekosky S, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer’s disease: correlation with cognitive severity. Ann Neurol. 1990;27:457–464.
Dulse sea lettuce is naturally high in trace minerals, iron and iodine. These elements are important for maintaining and supporting a healthy immune system.
Dulse has been clinically proven to possess free radical scavenging activity, making dulse useful as an antioxidant. The combination of constant stress, environmental pathogens, and malnutrition is harming many animals’ immune systems. Utilizing dulse and other antioxidants helps to repair compromised body tissues.
- “Extracts from dulse (Palmaria palmata) are effective antioxidants and inhibitors of cell proliferation in vitro.” Y.V. Yuan, et al. Food and Chemical Toxology, July 2005; 43(7):1073-81.
- “Nutritional value of proteins from edible seaweed Palmaria palmata (dulse),” A.V. Galland-Imouli, et al. The Journal of Nutritional Biochemistry, June 1999; 10(6): 353-9.
- Bauman College.org. “Hashimoto’s Autoimmune Thyroiditis: Eating for Health Applications for Recovery,” by Jody Friedlander, M.S. and Edward Bauman, M.Ed., Ph.D.
Bacopa monnieri is a traditional herb used to support brain functions including memory, focus, concentration and cognitive activity.
Studies indicate that Bacopa can dilate the brain blood vessels which can support brain function and CNS function to support a healthy immune system.
- Steven Roodenrys Ph.D,Dianne Booth MSc, Sonia Bulzomi G.Dip.App.Psyc Neuropsychopharmacology (2002) 27, 279–281. doi:10.1016/S0893-133X(01)00419-5
Chronic Effects of Brahmi (Bacopa monnieri) on Human Memory, Volume 2016 (2016), Article ID 4103423, 8 pages.
- Navneet Kumar, G. Abichandani, Vijay Thawani, K. J. Gharpure, M. U. R. Naidu, and G. Venkat Ramana Efficacy of Standardized Extract of Bacopa on Cognitive Functions of Medical Students: A Six-Week, Randomized Placebo-Controlled Trial.
- Evidence-Based Complementary and Alternative Medicine Volume 2012 (2012), Article ID 606424, 10 pages Research Article: Effects of 12-Week Bacopa monnieri Consumption on Attention, Cognitive Processing, Working Memory, and Functions of Both Cholinergic and Monoaminergic Systems in Healthy Elderly Volunteers.
CIC International™ contains Omega-3 fatty acids from Sacha Inchi nuts.
According to research studies Omega-3 fatty acids may help to boost the immune system by enhancing the functioning of immune cells.
- Study on Omega-3…to boost immune system by enhancing the functioning of immune cells, Journal of Leukocyte Biology, March 2020, Volume 107, Issue 3.
Camu Camu is a South American berry that contains very high levels of naturally occurring whole Vitamin C that is best for vitamin C activity including immune strengthening. The natural antiseptic qualities of Camu Camu make it ideal for fending off bacterial and viral infections, including E. coli and herpes. This makes Camu Camu a powerful dietary supplement for to support the immune system which is constantly under attack by foreign agents.
Moringa leaf is an exceptional nutrient-rich source of vitamins and minerals including iron which supports a healthy immune system. Moringa has bioactions related to anti-inflammatory activity and blood sugar balancing. Studies indicate Moringa supports immune response.
- Nfambi J, Bbosa GS, Sembajwe LF, Gakunga J, Kasolo JN. Immunomodulatory activity of methanolic leaf extract of Moringa oleifera in Wistar albino rats. J Basic Clin Physiol Pharmacol. 2015;26(6):603–611. doi:10.1515/jbcpp-2014-0104
- Abd El-Gawad, E.A., El Asely, A.M., Soror, E.I. et al. Effect of dietary Moringa oleifera leaf on the immune response and control of Aeromonas hydrophila infection in Nile tilapia (Oreochromis niloticus) fry. Aquacult Int 28, 389–402 (2020).
Bhringraj contains phytoconstituent compounds that studies have revealed may benefit the user with anticancer, hepatoprotective, snake venom neutralizing, anti-inflammatory, and antimicrobial properties which point to the immunomodulary action of Bhringraj. Traditional use of Bhringraj includes support of healthy hair and brain function.
- Ethnopharmacological Significance of Eclipta alba (L.) Hassk. Asteraceae) Rownak Jahan, Abdullah Al-Nahain, Snehali Majumder and Mohammed Rahmatullah, Department of Biotechnology & Genetic Engineering, University of Development Alternative, Dhanmondi, Dhaka 1209, Banglades, Published 29 October 2014
Guduchi is highly valued in traditional medicine for its rejuvenating, immune-boosting, and anti-rheumatic properties. It is now being studied and utilized in modern medicine for cold and flu prevention, immune support, skin disorders, arthritis, liver disorders, gout (and rheumatic disorders), and most recently to mitigate the negative effects of chemotherapy.
- David Frawley, Dr. Vasant Lad, The Yoga of Herbs: An Ayurvedic Guide To Herbal Medicine (Twin Lakes, WI: Lotus Press, 2001), pp. 4-5, 242-243.
- Giloy Herb: The Wonder Plant, Giloy: The origin and uses, http://giloyherb.com/index.php/articles/the-origin.
- M. Nadkarni, Indian Materia Medica (Bombay: Popular Prakashan, 1908), pp. 356-357.
- SVAyurveda: From Sutra to Science, Vaidya Mishra, “Guduchi–Learn About The Most Divine Herb In Ayurveda”, https://vaidyamishra.com/shop/media/dravya-guna-vigyan-ayurvedic-pharmacopoeia/guduchi-learn-about-the-most-divine-herb-in-ayurveda.html.
- The Chopra Center, Deepak Chopra, “Guduchi”, https://www.chopra.com/guduchi.
- Marc Halpern, D.C., C.A.S., P.K.S., Principles of Ayurvedic Medicine: Textbook for the Ayurvedic Profession, Tenth Edition (Nevada City, CA: California College of Ayurveda, 2012), pp. 249-250.
- Priyavrat Sharma (Editor-Translator), Caraka-Samhita: Agnivesa’s treatise refined and annotated by Caraka and redacted by Drbhabala (Varanasi: Chaukambha Orientalia, 2014), Vol. I. Ch. II [verses 11-14], Ch. III [verses 1-7, 22], Ch. IV [verses 18-19, 29, 41], Ch. XXV [verse 40], Ch. XXVI [verse 67], Vol. II, Ch. I [verses 30-31], Ch III [verses 200-203, 222-223], Ch XXVIII [verses 157-164]
Boswellia serrata herbal resin also known as Frankincense is used traditionally as an anti-inflammatory and used specifically to support good joint health.
Studies indicate Boswellia may be useful as an anti-cancer agent as an anti-proliferative. It is a potent inhibitor of angiogenesis and cell invasiveness. Also, studies indicate Boswellia may potently suppress tumor growth.
- Awab MA, et al. Development of a high-performance liquid chromatographic method for the determination of 11-keto-beta-boswellic acid in human plasma. J Chromatogr B Biomed Sci Appl. (2001)
- Woolley CL, et al. Chemical differentiation of Boswellia sacra and Boswellia carterii essential oils by gas chromatography and chiral gas chromatography-mass spectrometry. J Chromatogr A. (2012)
- De Rapper S, et al. The additive and synergistic antimicrobial effects of select frankincense and myrrh oils–a combination from the pharaonic pharmacopoeia. Lett Appl Microbiol. (2012)
- Blain EJ, Ali AY, Duance VC. Boswellia frereana (frankincense) suppresses cytokine-induced matrix metalloproteinase expression and production of pro-inflammatory molecules in articular cartilage. Phytother Res. (2010)
- Devi PR, et al. Safety Evaluation of Alcoholic Extract of Boswellia ovalifoliolata Stem-bark in Rats. Toxicol Int. (2012)
- Aiddiqui MZ. Boswellia serrata, a potential antiinflammatory agent: an overview. Indian J Pharm Sci. (2011)
- Gerbeth K, et al. Determination of major boswellic acids in plasma by high-pressure liquid chromatography/mass spectrometry. J Pharm Biomed Anal. (2011)
- Moussaieff A, et al. Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. FASEB J. (2008)
- Al-Harrasi A, Al-Saidi S. Phytochemical analysis of the essential oil from botanically certified oleogum resin of Boswellia sacra (Omani Luban). Molecules. (2008)
- Bhushan S, et al. Activation of p53/p21/PUMA alliance and disruption of PI-3/Akt in multimodal targeting of apoptotic signaling cascades in cervical cancer cells by a pentacyclic triterpenediol from Boswellia serrata. Mol Carcinog. (2009)
Turmeric has been used traditionally for anti-inflammatory conditions and to prevent inflammation and toxicity. Turmeric acts as an immunomodulator and helps support a healthy immune system.
- Chemistry and biological activities of C. longa.
- Kiuchi F, et al. Nematocidal activity of turmeric: synergistic action of curcuminoids. Chem Pharm Bull (Tokyo). (1993)
- Changtam C, et al. Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species. Eur J Med Chem. (2010)
- Qualitative and quantitative analysis of curcuminoids in herbal medicines derived from Curcuma species.
- Chang CJ, et al. Beneficial impact of Zingiber zerumbet on insulin sensitivity in fructose-fed rats. Planta Med. (2012)
- Zhou H, Beevers CS, Huang S. The targets of curcumin. Curr Drug Targets. (2011)
- Usharani P, et al. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R D. (2008)
- Venkataranganna MV, et al. NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOS. World J Gastroenterol. (2007)
- Esatbeyoglu T, et al. Curcumin-from molecule to biological function. Angew Chem Int Ed Engl. (2012)
- Scotter MJ. Methods for the determination of European Union-permitted added natural colours in foods: a review. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. (2011)
- Wang YJ, et al. Stability of curcumin in buffer solutions and characterization of its degradation products. J Pharm Biomed Anal. (1997)
- Sharma RA, et al. Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res. (2001)
Tulsi or Holy Basil is a traditional herb that has been revered for thousands of years as the “The Incomparable One” and was traditionally used to promote a positive stress response and the elevation of the spirit. Basil is also known to support anti-microbial action that supports a positive immune response.
- Hossain MA1, Kabir MJ, Salehuddin SM, Rahman SM, Das AK, Singha SK, Alam MK, Rahman A. “Antibacterial properties of essential oils and methanol extracts of sweet basil Ocimum basilicum occurring in Bangladesh”:Pharm Biol. 2010 May;48(5):504-11. doi: 10.3109/13880200903190977.
- Rattanachaikunsopon P1, Phumkhachorn P. “Antimicrobial activity of basil (Ocimum basilicum) oil against Salmonella enteritidis in vitro and in food.”: Biosci Biotechnol Biochem. 2010;74(6):1200-4. Epub 2010 Jun 7.
CIC International™ contains a proprietary blend of probiotics and prebiotics that support probiotics propagation in the intestines. Probiotics are known assist the immune system inhibiting the growth of harmful gut bacteria. Probiotics have been shown to promote the production of natural antibodies in the body. They may also boost specialty immune cells like the IgA-producing cells, T lymphocytes and natural killer cells.
Probiotics also keep the gut healthy, to ensure the immune system functions well. Probiotics can also modulate the immune system, enhancing the body’s innate immunity. This modulating effect helps alleviate excessive inflammation in the gut, thereby boosting immune function.
Here are the Prebiotics and Probiotics contained in CIC International:
- Fructo-oligosaccharides (FOS)
- Mannan-oligosaccharides (MOS)
- Lactobacillus acidophilus
- Enterococcus faecium
- Bifidobacterium lactis
- Lactobacillus casei
- Bifidobacterium breve
- Lactobacillus Plantarum